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Glycated Hemoglobin and All-Cause and Cause-Specific Mortality in Singaporean Chinese Without Diagnosed Diabetes: The Singapore Chinese Health Study

Identifieur interne : 002B65 ( Main/Exploration ); précédent : 002B64; suivant : 002B66

Glycated Hemoglobin and All-Cause and Cause-Specific Mortality in Singaporean Chinese Without Diagnosed Diabetes: The Singapore Chinese Health Study

Auteurs : Michael P. Bancks [États-Unis] ; Andrew O. Odegaard [États-Unis] ; James S. Pankow [États-Unis] ; Woon-Puay Koh [Singapour] ; Jian-Min Yuan [États-Unis] ; Myron D. Gross [États-Unis] ; Mark A. Pereira [États-Unis]

Source :

RBID : PMC:4237977

Descripteurs français

English descriptors

Abstract

OBJECTIVE

Glycated hemoglobin (HbA1c) is a robust biomarker of the preceding 2 to 3 months average blood glucose level. The aim of this study was to examine the association between HbA1c and mortality in a cohort of Southeast Asians.

RESEARCH DESIGN AND METHODS

Analysis of 7,388 men and women, mean age 62 years, from the Singapore Chinese Health Study who provided a blood sample at the follow-up I visit (1999–2004) and reported no history of diabetes, previous adverse cardiovascular events, or cancer. A total of 888 deaths were identified through 31 December 2011 via registry linkage. Participants represented a random study sample of potential control subjects for a nested case-control genome-wide association study of type 2 diabetes in the population. Hazard ratios (HRs) for all-cause and cause-specific mortality by six categories of HbA1c were estimated with Cox regression models.

RESULTS

Relative to participants with an HbA1c of 5.4–5.6% (36–38 mmol/mol), participants with HbA1c ≥6.5% (≥48 mmol/mol) had an increased risk of all-cause, cardiovascular, and cancer mortality during an average of 10.1 years of follow-up; HRs (95% CIs) were 1.96 (1.56–2.46), 2.63 (1.77–3.90), and 1.51 (1.04–2.18), respectively. No level of HbA1c was associated with increased risk of respiratory mortality. Levels <6.5% HbA1c were not associated with mortality during follow-up. The results did not materially change after excluding observation of first 3 years post–blood draw.

CONCLUSIONS

HbA1c levels consistent with undiagnosed type 2 diabetes (≥6.5%) are associated with an increased risk of all-cause and cause-specific mortality in Chinese men and women.


Url:
DOI: 10.2337/dc14-0390
PubMed: 25216509
PubMed Central: 4237977


Affiliations:


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<title>OBJECTIVE</title>
<p>Glycated hemoglobin (HbA
<sub>1c</sub>
) is a robust biomarker of the preceding 2 to 3 months average blood glucose level. The aim of this study was to examine the association between HbA
<sub>1c</sub>
and mortality in a cohort of Southeast Asians.</p>
</sec>
<sec>
<title>RESEARCH DESIGN AND METHODS</title>
<p>Analysis of 7,388 men and women, mean age 62 years, from the Singapore Chinese Health Study who provided a blood sample at the follow-up I visit (1999–2004) and reported no history of diabetes, previous adverse cardiovascular events, or cancer. A total of 888 deaths were identified through 31 December 2011 via registry linkage. Participants represented a random study sample of potential control subjects for a nested case-control genome-wide association study of type 2 diabetes in the population. Hazard ratios (HRs) for all-cause and cause-specific mortality by six categories of HbA
<sub>1c</sub>
were estimated with Cox regression models.</p>
</sec>
<sec>
<title>RESULTS</title>
<p>Relative to participants with an HbA
<sub>1c</sub>
of 5.4–5.6% (36–38 mmol/mol), participants with HbA
<sub>1c</sub>
≥6.5% (≥48 mmol/mol) had an increased risk of all-cause, cardiovascular, and cancer mortality during an average of 10.1 years of follow-up; HRs (95% CIs) were 1.96 (1.56–2.46), 2.63 (1.77–3.90), and 1.51 (1.04–2.18), respectively. No level of HbA
<sub>1c</sub>
was associated with increased risk of respiratory mortality. Levels <6.5% HbA
<sub>1c</sub>
were not associated with mortality during follow-up. The results did not materially change after excluding observation of first 3 years post–blood draw.</p>
</sec>
<sec>
<title>CONCLUSIONS</title>
<p>HbA
<sub>1c</sub>
levels consistent with undiagnosed type 2 diabetes (≥6.5%) are associated with an increased risk of all-cause and cause-specific mortality in Chinese men and women.</p>
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</TEI>
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